Smithsonian Magazine · People & society

Jonathan the Tortoise's DNA Offers Longevity Clues

Researchers analyzed the DNA of Jonathan, the world's oldest living land animal, an Aldabra giant tortoise estimated to be around 194 years old, to find genetic factors behind his lifespan.

The study identified 287 unique genetic variants in Jonathan related to DNA repair, inflammation reduction, and insulin management. He shares aging-related genes with cancer-resistant species like naked mole-rats.

Jonathan's epigenome showed youthful DNA repair and mitochondrial markers, similar to a juvenile tortoise, despite overall age-related epigenetic changes.

These findings suggest potential mechanisms for DNA endurance and align with observations in human supercentenarians, though causation is not proven.

Scientists aim to translate these insights into practical treatments for aging diseases, but further research is needed.

Limitations include incomplete DNA sequencing from a cheek swab (a blood sample was denied) and comparison against only a few other tortoises.

Generalizing findings from a single individual is challenging, and more extensive research is required before medical applications.

Jonathan has lived on Saint Helena since 1882, receiving care for age-related issues.

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