Futurity · Health

Immune System Aging Accelerates Around 40 and 60, With Sex Differences

New research reveals immune system aging occurs in accelerated waves around ages 40 and 60, with sex-specific changes that may explain disease disparities.

An analysis of nearly 2,000 individuals' immune cells indicates distinct periods of accelerated immune aging and sex-specific changes.

The study mapped how healthy immune cells change differently in men and women over time, potentially leading to personalized treatments.

Immune cells do not age uniformly; major gene activity shifts occur around age 40 and after 60.

T cells showed significant gene activity changes around age 40 and drove a second wave of changes after 60.

The study examined 3.8 million immune cells from healthy individuals aged 19 to 97.

AI models were developed to predict biological age for sex-tailored interventions.

Understanding these changes may explain increased susceptibility to infections and why autoimmune diseases disproportionately affect women.

AI-samenvatting op basis van de bron.